Radim Osicka Selected Research

Adenylate Cyclase Toxin

10/2021	Selective Enhancement of the Cell-Permeabilizing Activity of Adenylate Cyclase Toxin Does Not Increase Virulence of Bordetella pertussis.
8/2021	Bordetella Adenylate Cyclase Toxin Elicits Airway Mucin Secretion through Activation of the cAMP Response Element Binding Protein.
1/2021	Simultaneous Determination of Antibodies to Pertussis Toxin and Adenylate Cyclase Toxin Improves Serological Diagnosis of Pertussis.
1/2021	Almost half of the RTX domain is dispensable for complement receptor 3 binding and cell-invasive activity of the Bordetella adenylate cyclase toxin.
1/2019	Distinct Spatiotemporal Distribution of Bacterial Toxin-Produced Cellular cAMP Differentially Inhibits Opsonophagocytic Signaling.
1/2018	Bordetella pertussis Adenylate Cyclase Toxin Disrupts Functional Integrity of Bronchial Epithelial Layers.
1/2018	Bordetella Pertussis Adenylate Cyclase Toxin Does Not Possess a Phospholipase A Activity; Serine 606 and Aspartate 1079 Residues Are Not Involved in Target Cell Delivery of the Adenylyl Cyclase Enzyme Domain.
1/2017	Cyclic AMP-Elevating Capacity of Adenylate Cyclase Toxin-Hemolysin Is Sufficient for Lung Infection but Not for Full Virulence of Bordetella pertussis.
4/2016	Transmembrane segments of complement receptor 3 do not participate in cytotoxic activities but determine receptor structure required for action of Bordetella adenylate cyclase toxin.
1/2016	Negatively charged residues of the segment linking the enzyme and cytolysin moieties restrict the membrane-permeabilizing capacity of adenylate cyclase toxin.

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Radim Osicka Research Topics

Disease

16	Whooping Cough (Pertussis) 10/2021 - 10/2003
8	Infections 02/2022 - 04/2003
2	Neoplasms (Cancer) 10/2014 - 08/2014
2	Starvation 12/2006 - 02/2005
1	Cough 08/2021
1	Sneezing 08/2021
1	Atrophic Rhinitis (Ozena) 01/2020
1	Edema (Dropsy) 01/2019
1	Pathologic Processes 12/2016
1	Bordetella Infections 10/2014
1	Melanoma (Melanoma, Malignant) 08/2014
1	Communicable Diseases (Infectious Diseases) 08/2014
1	Pleuropneumonia 01/2012

Drug/Important Bio-Agent (IBA)

14	Adenylate Cyclase ToxinIBA 10/2021 - 10/2003
8	Hemolysin Proteins (Hemolysins)IBA 10/2021 - 10/2014
5	Virulence Factors (Pathogenicity Factors)IBA 01/2018 - 10/2003
5	VaccinesIBA 12/2016 - 01/2012
4	AntigensIBA 01/2021 - 01/2012
4	Complement Receptors (Complement Receptor)IBA 01/2021 - 12/2015
4	Proteins (Proteins, Gene)FDA Link 08/2013 - 04/2003
3	IntegrinsIBA 01/2017 - 12/2015
2	Adenylyl Cyclases (Adenylyl Cyclase)IBA 08/2021 - 01/2019
2	ToxoidsIBA 08/2021 - 10/2014
2	AntibodiesIBA 01/2021 - 08/2013
2	Hemagglutinins (Hemagglutinin)IBA 01/2021 - 01/2016
2	IronIBA 12/2006 - 02/2005
1	Cytotoxins (Cytolysins)IBA 02/2022
1	Adenosine Triphosphate (ATP)IBA 10/2021
1	AerosolsIBA 08/2021
1	MucinsIBA 08/2021
1	Acellular VaccinesIBA 01/2021
1	pertactin FDA Link 01/2021
1	Immunoglobulin G (IgG)IBA 01/2021
1	Pertussis ToxinIBA 01/2021
1	2,6-dinitrotoluene (DNT)IBA 01/2020
1	Adenosine Monophosphate (AMP)IBA 01/2019
1	Calmodulin (Calcium-Dependent Activator Protein)IBA 01/2019
1	Histocompatibility Antigens Class IIIBA 01/2017
1	Cyclic AMP (AMP, Cyclic)IBA 01/2017
1	EnzymesIBA 01/2017
1	Indicators and Reagents (Reagents)IBA 12/2016
1	Interleukin-10 (Interleukin 10)IBA 10/2014
1	Interleukin-12 (IL 12)IBA 10/2014
1	Type III Secretion SystemsIBA 08/2013
1	Subunit VaccinesIBA 01/2012
1	Protein Subunits (Protein Subunit)IBA 01/2012
1	CalciumIBA 01/2012
1	ProteomeIBA 12/2006